Our Pipeline
TocopheRx Pipeline
TOP001 has both FSH and LH activity at a ratio of 5:1. TOP002 has predominantly FSH activity. TOP001 and TOP002 are being developed for ovulation induction and in vitro fertilization cycles in women and for non-obstructive mild-moderate-severe oligospermia in men.
Scientific Breakthrough
FSH (blue; 33kD) and the inactive FSH receptor (magenta & gray; 75 kD), are both large proteins. TocopheRx has successfully developed innovative small molecules (gold) that directly activate the transmembrane domain (green). TocopheRx allosteric agonists (TOPs) enhance the response of the FSH receptor when a small amount of FSH is present, or act as a receptor agonist in the absence of endogenous FSH.
